Be The Match BioTherapies History

Successful cell therapy management and delivery for 30+ years

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Our mission statement is clear: we save lives through cellular therapy. At Be The Match BioTherapies®, we believe every patient should have access to the best therapy to treat their disease.

We were established as part of the National Marrow Donor Program® (NMDP)/Be The Match®, a pioneer in the field of one of the first cell therapies — hematopoietic stem cell transplant (HSCT). The NMDP/Be The Match and our partners have helped improve HSCT availability and outcomes for patients around the world.

We’ve done so through decades of experience, a global cell collection network and a research collaboration, the CIBMTR® (Center for International Blood and Marrow Transplant Research®).

But our leaders knew transplant wasn’t always the best therapy for every patient. They also knew the experience and relationships we developed over decades could help cell and gene therapy companies bring emerging therapies to patients sooner.

From that knowledge, Be The Match BioTherapies emerged.

Extending our life-saving mission to new cell and gene therapies

In 2016, we began partnering with leading cell and gene therapy companies to save more lives through autologous and allogeneic cellular therapy. Be The Match BioTherapies signed our first contract in February 2016 to provide cell sourcing and supply chain management services for the development of allogeneic cell therapies.

Less than two months later, we successfully delivered the first cellular starting material for manufacture for our partner.

Today, Be The Match BioTherapies works with more than 40 cell and gene therapy companies. These companies range from small, start-ups to large pharmaceutical companies. They rely on the expertise our team developed over nearly 35 years of delivering time-critical cell therapies to patients.


A recent history with deep roots in cellular therapy

While Be The Match BioTherapies has a recent history, our roots are deep as part of the NMDP/Be The Match.

You may know the NMDP/Be The Match for managing Be The Match Registry®. It is the world’s most diverse registry of volunteer blood stem cell donors. But you might not know how managing the registry led to systems, processes and a network of contracted centers that make us the ideal partner for cell and gene therapy companies.

From the first cell therapy delivered to 108,000

The story starts in 1987 when the NMDP/Be The Match managed our first donor search and bone marrow transplant. It was just one year after our establishment as the national registry of volunteer bone marrow donors for the United States.

Since then, our organization has managed more than 108,000 cell therapies, bringing life-saving therapies to people around the globe. We did so by developing cell sourcing expertise and a predictive search algorithm, HapLogicSM, for customized donor selection. And by developing the relationships and expertise to navigate cell therapy supply chain complexities, coordinate logistics and deliver time-critical therapies on time.

Investing in the future of cell therapy through research

During that time, we invested in cell therapy research. Our goal: to expand treatment options and find answers to save more lives and improve the quality of life for patients.

For example, in 2001, we built our Research Sample Repository. It’s one of the world’s largest tissue sample storage facilities used for medical research. The Repository provides researchers with access to more than 186,000 samples in inventory, with multiple aliquots available for each sample.

In 2004, the NMDP/Be The Match and the Medical College of Wisconsin partnered to merge research operations and create the CIBMTR. With the organizations collecting health outcomes data worldwide for decades prior to partnering, the CIBMTR’s data spans 45 years. Today, its research database contains information on more than 575,000 patients from more than 330 different centers.

The organization knows research is the only way to save more lives and enrich patients’ quality of life. Since inception, the collaboration has resulted in more than 1,500 publications. The CIBMTR currently has more than 225 active studies.

The CIBMTR implemented a Cellular Therapy Registry that accurately captures the nature, sequence and effects of modern cellular therapies, including CAR-T cells. Today the CIBMTR provides long-term follow-up tracking for the first two FDA-approved CAR-T therapies, Kite’s YESCARTA® and Novartis’s Kymriah®.

Partnerships support the development of next-generation cell and gene therapies

Today, our partnerships extend beyond the 40+ cell and gene therapy companies we work with to provide cell sourcing, cell therapy supply chain services, research support, outcomes tracking and more.

We’ve developed strategic partnerships with many service providers whose focused expertise compliments our own. Their expertise ranges from temperature-controlled logistics to sophisticated cell and gene therapy supply chain tracking. This allows us to provide integrated solutions and improved operations for cell and gene therapy companies.

And, we’ve launched efforts to establish international standards across the cell and gene therapy industry. In partnership with key industry stakeholders, we’re prioritizing standardization in apheresis collections, supply chain logistics and outcomes data tracking.

While we’re proud of our history, we’re looking forward to partnering with more cell and gene therapy companies on the development of next-generation therapies. Together, we’ll save more lives through cellular therapy.